Dangers of non sedating antihistamines pubmed


antagonism and are associated with fewer adverse effects compared with the first generation antihistamines.A number of drugs in this class are approved for use: acrivastine, astemizole, azelastine, cetirizine, ebastine, fexofenadine, loratadine, mizolastine and terfenadine. Currently the only FDA-approved histamine antagonist medications block the effects of histamine at H1 or H2 receptor sites. 6 Antihistamine medications block or reduce histamine-mediated effects at one of four identified histamine receptors (see Table 1 below).These include the first-generation H1 antagonists, or sedating antihistamines (eg, diphenhydramine, chlorpheniramine), and second-generation H1 receptor blockers, or nonsedating antihistamines (eg, loratadine, cetirizine).First-generation antihistamines are widely available without a prescription and commonly used to treat allergic symptoms, including rhinitis, conjunctivitis, pruritus, eczema, urticaria, and anaphylactic reactions.‘Condition improved’ was the most common event and reason for stopping.Headache/migraine was uncommon but associated with starting treatment (IDobs ratio 3.99 [95% CI 1.70, 10.83]).



After 2 months, 36.8% (n = 2464) of patients were still taking desloratadine.Cardiovascular events occurred rarely or very rarely, as did central and peripheral nervous system events.No serious adverse drug reactions (ADRs) were reported.The DSRU has received such funds from the manufacturer of desloratadine.



Dangers of non sedating antihistamines pubmed comments


  • Is my antihistamine safe? Request PDF profil de paulette60

    paulette60

    DOI 10.1016/S1084-628X9790134-9 Source PubMed. Cite this publication. Dangers of non-sedating antihistamines. August 1997 The Lancet Impact Factor.…
  • URTICARIA AND ANGIOEDEMA profil de paulette60

    paulette60

    URTICARIA AND ANGIOEDEMA. There are many different types including non-sedating and sedating antihistamines, as well as short acting and long acting types.…
  • A S WOROBEC Researcher Profile profil de paulette60

    paulette60

    A S WOROBEC published 5 Research Articles on Mastocytosis Hematologic Diseases Acute Disease Anaphylaxis. Dangers of non-sedating antihistamines.…
  • Oral Antihistamines List of Names and Side Effects profil de paulette60

    paulette60

    Second generation antihistamines are less sedating than their. Non-drug interventions should. Take the Summer Skin Hazards Quiz and clue in on the dangers to.…